Monday, May 21, 2012

New Research: Hidrox® Inhibits E. coli and Reduces Neuroinflammation


While nutraceuticals and dietary supplements undergo regulatory scrutiny for a perceived lack of verifiable claims, Creagri Inc., continues to achieve new scientific advancements on the road to producing healthy consumer goods.

WEBWIRE – Thursday, April 26, 2012
Hayward, CA - April 26, 2012 - While nutraceuticals and dietary supplements are coming under increasing regulatory scrutiny, both in the United States and Europe, for what is perceived to be a lack of verifiable scientific research supporting their claim to beneficial health effects, Creagri Inc., and Hidrox--its patented formulation of olive polyphenols rich in the potent antioxidant Hydroxytyrosol—continue to achieve new scientific advancements on the road to producing healthy consumer goods.
According to the Canadian Medical Association Journal (Apr. 17, 2012) consumers seek solutions to their health needs with proven clinical outcomes, backed by sound scientific evidence and reproducible test results.
In this area, the dietary supplement industry falls short of the mark. for example a recent an NBC Dateline report highlighted the problem of under-reported levels of selenium levels in some liquid vitamin products, and the practice of “dry labbing”, whereby a company claims to have done scientific research with its product when in fact, the research has been done by another institution with a similar ingredient or with a different product altogether. A spike in dry labbing claims was registered recently when the EFSA (the European Food Safety Agency, analogous to the FDA in the United States) announced that it was allowing claims relating to the beneficial effects of olive polyphenols and hydroxytyrosol in the prevention of LDL oxidation. Manyany companies promoting olive derived products quickly claimed this finding as their own while in reality very few may be able to show any study, let alone clinical trials, done with their product. This is not the case for CreAgri Inc., which starting in 1999 has conducted and published in peer-reviewed journals a number of human clinical trials and laboratory tests with its products, Hidrox and Olivenol plus. These studies are not only in the cardiovascular arena, but also in other inflammation driven conditions such as psoriasis, osteo and rheumatoid arthritis and neuroinflammation. Furthermore, EFA’s established minimum daily dosage of 5mg hydroxytyrosol came as no surprise to CreAgri. In fact, this was the daily dose of hydroxytyrosol that was adopted by the Tokyo Vascular Disease Institute and at the University of Arizona in two ground breaking clinical trials with Hidrox where a formulation of Olivenol, 2 capsules/day, containing a total of 600 mg of Hidrox 2% was given to patients with cardiovascular and arthritic conditions.
Now two new fundamental studies about the antibacterial and the neuroprotective effects of Hidrox have been published by the Journal of Agricultural and Food Chemistry and AgroFOOD Industry HiTech, two preeminent peer reviewed journals. The first study, by researchers at the USDA Regional Field Office, in Albany, California, has established the efficacy of Hidrox in inactivating E. coli and reducing the formation of carcinogenic amines in cooked beef patties. The second research study, a collaboration with scientists at The Parkinso’s Institute in Sunnyvale, CA., CreAgri has confirmed the efficacy of Hidrox® in inhibiting cytokine production in a Parkinson’s cell based model of neuroinflammation.
“Scientific research with Hidrox®) has registered positive results in the first quarter of 2012”, declares Dr. Roberto Crea, CreAgri’s CEO, and CSO. “Research and development on the applications with olive polyphenols and hydroxytyrosol are not only Creagri’s bread and butter, but are also an imperative for companies striving to create safe and healthy consumer products that have proven and verifiable efficacy.”
About HIDROX®
HIDROX® is CreAgri’s proprietary hydroxytyrosol-rich formulation of olive polyphenols produced from the juice of organic olives, and scientifically recognized for its anti-inflammatory and immune-modulating properties. HIDROX® is the first hydroxytyrosol formula with GRAS certification. HIDROX® is also certified organic, Kosher and Halal, and is protected by the largest number of US and international patents and applications.
About CreAgri
CreAgri Inc., a California company, is the inventor and developer of HIDROX®. Its goal is to promote health and wellness by creating superior natural products that strike a Creative Balance Between Nature and Technology®. The company develops science-based processes that are environmentally friendly and compatible with sustainable agricultural methods.http://www.webwire.com/ViewPressRel.asp?aId=155901

Monday, April 16, 2012

USDA and the University of Arizona published research proves OLIVENOL®  plus, active ingredient's efficacy in inactivating E.coli and reducing carcinogenic compounds in cooked beef patties.

Thursday, April 12, 2012

USPTO Recognizes CreAgri, Inc. as First to Discover the Anti-Inflammatory Properties of Hydroxytyrosol

A must read!!

The United States Patent and Trademark Office has recognized CreAgri, Inc. (The makers of OLIVENOL plus) as the first company to discover the anti-inflammatory healing benefits of Hydroxytyrosol.

USPTO Recognizes CreAgri, Inc. as First to Discover the Anti-Inflammatory Properties of Hydroxytyrosol

Tuesday, January 31, 2012

Health from the Olive

phytonutrient content, olives are nothing short of astounding. Few high-fat foods offer such a diverse range of antioxidant and anti-inflammatory nutrients - some of which are unique to olives themselves. The list below shows some key phytonutrients in olives, organized by their chemical category:
  • Simple Phenols
    • tyrosol
    • hydroxytyrosol
  • Terpenes (including secoiridoids and triterpenes)
    • oleuropein
    • demethyloleuropein
    • erythrodiol
    • uvaol
    • oleanolic acid
    • elenoic acid
    • ligstroside
  • Flavones
    • apigenin
    • luteolin
  • Hydroxycinnamic acids
    • caffeic acid
    • cinnamic acid
    • ferulic acid
    • coumaric acid
  • Anthocyanidins
    • cyanidins
    • peonidins
  • Flavonols
    • quercetin
    • kaempferol
  • Hydroxybenzoic acids
    • gallic acid
    • protocatechuic acid
    • vanillic acid
    • syringic acid
  • Hydroxyphenylacetic acids
    • homovanillic acid
    • homveratric acid
Given this phytonutrient richness, it's not surprising that olives have documented health benefits that extend to most of our body systems. Olive benefits have been demonstrated for the cardiovascular system, respiratory system, nervous system, musculoskeletal system, immune system, inflammatory system, and digestive system. We believe that many of these diverse systems benefits are actually related to two underlying health-support aspects of olives, namely, their unusual antioxidant and anti-inflammatory nutrients. In this Health Benefits section, we will focus on those antioxidant and anti-inflammatory properties of olives, as well as some anti-cancer benefits that seem especially important with respect to this food.
Antioxidant Benefits
The vast majority of olive phytonutrients listed at the beginning of this section function as antioxidants and help us avoid unwanted problems due to oxidative stress. "Oxidative stress" is a situation in which our cells are insufficiently protected from potential oxygen damage, and oxidative stress can often be related to an insufficient supply of antioxidant nutrients. Olives are a good source of the antioxidant vitamin E, and they also contain small amounts of antioxidant minerals like selenium and zinc. However, it's the phytonutrient content of olives that makes them unique as an antioxidant-rich food.
Perhaps the best-studied antioxidant phytonutrient found in olives is oleuropein. Oleuropein is found exclusively in olives, and it's been shown to function as an antioxidant nutrient in a variety of ways. Intake of oleuropein has been shown to decrease oxidation of LDL cholesterol; to scavenge nitric oxide (a reactive oxygen-containing molecule); to lower several markers of oxidative stress; and to help protect nerve cells from oxygen-related damage.
One recent study that caught our attention has shown the ability of olives to increase blood levels of glutathione (one of the body's premier antioxidant nutrients). In a very interesting research twist, study participants were not given fresh olives to eat but rather the pulpy residue from olives that had been previously milled to produce olive oil. Consumption of this olive pulp was associated with significantly increased glutathione levels in the blood of the participants, and improvement in their antioxidant capacity.
Interestingly, there may be common trade-offs made in the levels of different olive antioxidants during the maturation of olives on the tree. For example, the vitamin E content of olives may increase during early ripening when the total phenolic antioxidants in olives are slightly decreasing. Later on in the maturation process, these trends may be reversed.
Anti-Inflammatory Benefits
In addition to their function as antioxidants, many of the phytonutrients found in olives have well-documented anti-inflammatory properties. Extracts from whole olives have been shown to function as anti-histamines at a cellular level. By blocking special histamine receptors (called H1 receptors), unique components in whole olive extracts help to provide us with anti-inflammatory benefits. In addition to their antihistamine properties, whole olive extracts have also been shown to lower risk of unwanted inflammation by lowering levels of leukotriene B4 (LTB4), a very common pro-inflammatory messaging molecule. Oleuropein - one of the unique phytonutrients found in olives - has been shown to decrease the activity of inducible nitric oxide synthase (iNOS). iNOS is an enzyme whose overactivity has been associated with unwanted inflammation. Taken as a group, these research findings point to olives as a uniquely anti-inflammatory food.
The anti-inflammatory benefits of olives have been given special attention in the area of cardiovascular health. In heart patients, olive polyphenols have been determined to lower blood levels of C-reactive protein (CRP). CRP is a widely used blood measurement for assessing the likelihood of unwanted inflammation. Olive polyphenols have also been found to reduce activity in a metabolic pathway called the arachidonic acid pathway, which is central for mobilizing inflammatory processes.
Anti-Cancer Benefits
The antioxidant and anti-inflammatory properties of olives make them a natural for protection against cancer because chronic oxidative stress and chronic inflammation can be key factors in the development of cancer. If our cells get overwhelmed by oxidative stress (damage to cell structure and cell function by overly reactive oxygen-containing molecules) and chronic excessive inflammation, our risk of cell cancer is increased. By providing us with rich supplies of antioxidant and anti-inflammatory nutrients, olives can help us avoid this dangerous combination of chronic oxidative stress and chronic inflammation.
Research on whole olives and cancer has often focused on two cancer types: breast cancer and stomach (gastric) cancer. In the case of breast cancer, special attention has been paid to the triterpene phytonutrients in olives, including erythrodiol, uvaol and oleanolic acid. These olive phytonutrients have been shown to help interrupt the life cycle of breast cancer cells. Interruption of cell cycles has also been shown in the case of gastric cancer, but with this second type of cancer, the exact olive phytonutrients involved are less clear.
One of the mechanisms linking olive intake to cancer protection may involve our genes. Antioxidant phytonutrients in olives may have a special ability to protect DNA (deoxyribonucleic acids) - the key chemical component of genetic material in our cells - from oxygen damage. DNA protection from unwanted oxidative stress means better cell function in wide variety of ways and provides cells with decreased risk of cancer development

Wednesday, January 4, 2012

Tuesday, January 3, 2012

Ava Fabian, Olivenol Will Protect Me!

Watch and Enjoy Ava Fabian: actress/model and hear her Olivenol plus Testimony. Thank you for sharing Ava!